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In parallel, the increased Kyn/Trp ratio in symptomatic patients supports the presence of inflammatory activation

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C., Brnfort, G., & van der Heijden, G

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Recent investigations have also expanded the scope of AD-related inflammation, exploring how the gut microbiota, oral microbiome, and viruses such as herpesviruses and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) impact neuroinflammation

The next decade will be pivotal in translating accumulating clinical and preclinical findings into meaningful therapies that can prevent or reverse the course of DN, ultimately improving outcomes for millions of patients